ABSTRACT
Presentación de un caso clínico en el que la terapia con dasatinib y la quimioterapia se asociaron con supervivencia a largo plazo en un paciente de 51 años, diagnosticado con mastocitosis sistémica y un mal pronóstico inicial.
Subject(s)
Humans , Male , Middle Aged , Leukemia, Myeloid, Acute/diagnosis , Leukemia, Myeloid, Acute/drug therapy , Leukemia, Myeloid, Acute/therapy , Mastocytosis/complications , Mastocytosis/drug therapy , Mastocytosis/therapyABSTRACT
The effects of anti-allergic drugs on intestinal mastocytosis and the expulsion of Neodiplostomum seoulense were observed in Sprague-Dawley rats, after oral infection with 500 metacercariae. The drugs used were hydroxyzine (a histamine receptor H1 blocker), cimetidine (a H2 blocker), cyclosporin-A (a helper T-cell suppressant), and prednisolone (a T- and B-cell suppressant). Infected, but untreated controls, and uninfected controls, were prepared. Worm recovery rate and intestinal mastocytosis were measured on weeks 1, 2, 3, 5, and 7 post-infection. Compared with the infected controls, worm expulsion was significantly (P < 0.05) delayed in hydroxyzine- and cimetidine-treated rats, despite mastocytosis being equally marked in the duodenum of all three groups. In the cyclosporin-A- and prednisolone-treated groups, mastocytosis was suppressed, but worm expulsion was only slightly delayed, without statistical significance. Our results suggest that binding of histamine to its receptors on intestinal smooth muscles is more important in terms of the expulsion of N. seoulense from rats than the levels of histamine alone, or mastocytosis.
Subject(s)
Animals , Rats , Cimetidine/pharmacology , Cyclosporine/pharmacology , Histamine H1 Antagonists/pharmacology , Histamine H2 Antagonists/pharmacology , Hydroxyzine/pharmacology , Immunosuppressive Agents/pharmacology , Intestinal Diseases, Parasitic/drug therapy , Mastocytosis/drug therapy , Prednisolone/pharmacology , Rats, Sprague-Dawley , Trematoda/growth & development , Trematode Infections/drug therapyABSTRACT
La telangiectasia macularis eruptiva perstans (TMEP) es una forma de mastocitosis cutánea poco frecuente, que se manifiesta casi exclusivamente en adultos. Su diagnóstico es básicamente clínico y no se dispone hasta la actualidad de una terapéutica específica eficaz. Se presentan cuatro pacientes de sexo masculino, edad promedio de 54 años, con manifestaciones clínicas e histológicas de TMEP, en diferentes períoddos de evolución. Todos presentaron patología úlcero éptica, asociación frecuente de las mastocitosis cutáneas. Objetivo: Presentación clínica de una forma poco frecuente de mastocitosis cutánea y revisión de la bibliografía
Subject(s)
Humans , Male , Middle Aged , Mastocytosis/diagnosis , Telangiectasis/diagnosis , Mastocytosis/drug therapy , Mastocytosis/therapy , Telangiectasis/drug therapy , Telangiectasis/pathology , Peptic Ulcer/complicationsSubject(s)
Humans , Infant , Child, Preschool , Child , Adolescent , Adult , Mastocytosis/diagnosis , Mastocytosis/drug therapy , Mastocytosis/epidemiology , Urticaria Pigmentosa/diagnosis , Epinephrine/administration & dosage , Epinephrine/therapeutic use , Histamine H1 Antagonists/therapeutic use , Histamine H2 Antagonists/therapeutic use , Hydroxyzine/administration & dosage , Hydroxyzine/therapeutic use , Ketotifen/administration & dosage , Ketotifen/therapeutic use , Precipitating FactorsABSTRACT
Sao apresentados dois casos de mastocitose sistemica benigna secundaria a urticaria pigmentosa (up), com evolucao clinica superior a 16 anos. Em um dos casos a UP iniciou-se aos dois meses de idade e evoluiu para forma sistemica em menos de dois anos. Em outro paciente a UP iniciou-se aos 22 anos de idade e o diagnostico de MSB foi realizado apos 30 anos de evolucao. Ambos os casos apresentavam lesoes cutaneas, hepatoesplenomegalia e sintomas gastrointestinais. Mielograma demonstrou envolvimento medular; em um caso a biopsia revelou mielofibrose. A terapeutica com antagonistas histaminicos "H IND. 1" e "H IND. 2" com cetotifeno ofereceu bom controle dos sintomas.